Therapeutic Strategies for Mutant SPAST-Based Hereditary Spastic Paraplegia
Mutations The fracture resistance of 3D-printed versus milled provisional crowns: An in vitro study of the SPAST gene that encodes the microtubule-severing enzyme called spastin are the chief cause of Hereditary Spastic Paraplegia.Growing evidence indicates that pathogenic mutations functionally compromise the spastin protein and endow it with toxi