Therapeutic Strategies for Mutant SPAST-Based Hereditary Spastic Paraplegia

Therapeutic Strategies for Mutant SPAST-Based Hereditary Spastic Paraplegia

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Mutations The fracture resistance of 3D-printed versus milled provisional crowns: An in vitro study of the SPAST gene that encodes the microtubule-severing enzyme called spastin are the chief cause of Hereditary Spastic Paraplegia.Growing evidence indicates that pathogenic mutations functionally compromise the spastin protein and endow it with toxic gain-of-function properties.With each of these two factors potentially relevant to disease etiology, the present article discusses possible therapeutic strategies that may ameliorate symptoms in patients suffering from SPAST-based Hereditary Spastic Paraplegia, Development of sarcopenia-based nomograms predicting postoperative complications of benign liver diseases undergoing hepatectomy: A multicenter cohort study which is usually termed SPG4-HSP.